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Unlike homocysteine, which responds to both B12 and folate intake, the metabolite methylmalonic acid (MMA) specifically responds to B12 intake, and for some time we viewed MMA levels as the most important measure of B12 activity

A considerable percentage of the worlds population has at least one variant of this gene

The boxed-warning row is important and asymmetric: because tirzepatide is approved, its rodent thyroid C-cell finding is formally carried on the label as a warning, whereas CagriSema simply has no label yet

doi: 10.1152/ajpendo.1995.268.6.E1192

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