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Multiple biological replicates were available for G

As indicators of glucose responsiveness of a molecule, larger ED 50, and T 1/2 value suggests lower glucose sensitivity and slower response time of this molecule, respectively

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A recent study (99) proposed that the ATF4/CHOP/ChaC1 signaling pathway might be vital for apoptosis induced by crosstalk between oxidative and ER stress

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However, identifying responsive tumor subpopulations remains a major obstacle in developing metabolism-targeted therapies, as metabolic vulnerabilities vary among cancers with different oncogene expression profiles