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Some patients plateau in weight loss at a particular dose, signaling readiness to increase

Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity

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Growth factors are not simply involved in driving growth of the tumour, they can also impact the tumour microenvironment (Zhang et al., 2010), and cancer-cell de-differentiation (Nakano et al., 2019)

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In November 2023, the FDA granted approval for Zepbound (tirzepatide) for chronic weight management in adults with obesity (body mass index 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbid condition such as hypertension, dyslipidemia, type 2 diabetes, obstructive sleep apnea, or cardiovascular disease