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Individuals with Vitamin B12 deficiency may notice improvement as deficiency is corrected

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The widely repeated claim that it is ~ten-million-fold more potent than BDNF is a relative in-vitro spine-counting ratio, not a human effect, and key mechanism papers from the originating lab were retracted in 2025

It may help address myofascial components sometimes present in fibromyalgia

Gut and Liver, 14(2), 153-167