National Institute for Health and Care Excellence (NICE) (2022) Type 2 diabetes in adults: management
Intern Emerg Med 20 , 4764 (2025)
Using prescription data, we evaluated both overall prescribing rates across all GLP-1s, with a focus on AOM tirzepatide and AOM semaglutide
Weight reduction by 5 % to 10 % typically improves these odds, though for people with severe obesity (for example, BMI 35 kg/m), 15 % to 20 % weight loss is a more meaningful target
may pose choking risk in those with swallowing difficulties) Glucomannan (must be taken with sufficient water to avoid choking or oesophageal/intestinal obstruction) Inulin and other prebiotics These may indirectly support incretin secretion by slowing carbohydrate absorption, promoting beneficial gut bacteria, and stimulating L-cells in the intestine
This is particularly helpful if you have had a high-stress day or a very intense workout