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Consistently, knocking down HNF4 by siRNAs significantly reduced the mRNA and/or protein levels of these key SAA metabolic enzymes in HNF4-positive HepG2, Huh7, and HepB3 cells (Fig

Data collection was carried out using the software Sparkcontrol (2.3)

doi: 10.1002/biof.5520170112

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Xiao F, Li H-L, Yang B et al (2024) Disulfidptosis: A new type of cell death

However, these same trials documented various side effects that occur during the initial dose-escalation phase, including gastrointestinal symptoms and fatigue in a portion of participants