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Whether similar changes in these enzymes are also evident in other organs is not certain as they were not determined in this study but the presence of these differences in the kidney during the pre-hypertensive period suggests a potential role for them in the pathogenesis of hypertension

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Expression of LaccID and engineered receptors was verified at 96 h after transduction by flow cytometry (day 5)

Amycretin shows potentially superior weight loss (up to 24.3% in Phase 1b/2a) compared to semaglutide (14.9% in STEP 1), driven by its dual GLP-1/amylin mechanism in a single molecule

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