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Alleviated some pain, but relief was only temporary

For more information on B-vitamin safety, the Linus Pauling Institute at Oregon State University is a great resource

The adverse-event profile published in that trial and the subsequent 52-week safety extension is what FDA labeling for the active ingredient is built around

Last reviewed: June 12, 2026 Last updated: June 12, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

While it can promote tumor cell survival under metabolic stress by recycling cellular components (4), it may also trigger tumor-suppressive effects through autophagic cell death (5)

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