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Radiolabeled receptor binding assays show oxyntomodulin binds to the GLP-1R with an approximate 10-fold reduction in potency relative to native GLP-1, with a comparative 100-fold reduction in cAMP potency, indicating the extent of oxyntomodulins 8 amino acid C-terminal extension in conferring additional promiscuity at the GLP-1R [41]

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The GIP component adds metabolic benefits that amplify the appetite suppression and blood sugar regulation that GLP-1 provides alone

J Biol Chem (1990) 265(31):193128

Gene expression of membrane transporters: importance for prognosis and progression of ovarian carcinoma

These indirect costs affect how systems are designed, operated, and maintained