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Repeatedly using the same area can cause tissue damage, reduce absorption efficiency, and increase discomfort

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Reported adverse effects of IV glutathione include adverse cutaneous eruptions including potentially fatal Stevens-Johnson syndrome and toxic epidermal necrolysis, severe abdominal pain, thyroid dysfunction, renal dysfunction, and lethal complications such as air embolism or potentially fatal sepsis due to incorrect/unsterile method of IV administration, with side effects on the use of injectable glutathione for skin lightening including toxic effects on the liver, kidneys, and nervous system

In 1998, Gagliardi et al

The experimental apparatus consisted of a wooden brown open box (41 cm 41 cm 41 cm) with two identical objects (a small black jewelry box) positioned equidistantly from the center