Additionally, NAD + is required for fatty acid metabolism during -oxidation, glutaminolysis generating -ketoglutarate, mitochondrial shuttling of metabolites, and lactic acid fermentation 3,4,5
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Although not much evidence is found, it is proposed that carotenoids can also display pro-oxidant effects especially through autoxidation in the presence of high concentrations of oxygen-forming hydroxyl radicals [54]
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The mechanism proposed involves chromatin remodeling at the hTERT promoter specifically, a reduction in the repressive histone modifications (H3K9me3, H3K27me3) that maintain transcriptional silencing in somatic cells allowing activating transcription factors to access promoter binding sites and initiate hTERT transcription
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