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Clinical Necessity Is Required for Compounded GLP-1 Prescriptions Under current 503A regulations, a compounding pharmacy may only prepare semaglutide or tirzepatide formulations that represent a clinically significant difference from the commercially available product

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Remarkably, there is evidence that GLP-1 agonists can enhance left ventricular ejection fraction, inotropy, coronary blood flow, cardiac output, and vascular endothelial function because of their cardiovascular effects and decrease overall cardiovascular event risks