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I think if you are somebody who has severe obesity or has struggled with this all their life, I feel like most of those folks are probably either on a GLP-1 or on the path to it because the success level is so clear

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However, as we observed sex differences with semaglutide, assessing sex-specific responses to tirzepatide and retatrutide will be essential to fully characterize their therapeutic potential for AUD

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This is particularly relevant for: Short-acting agents (exenatide immediate-release, lixisenatide) May require timing separation from oral medications, particularly those requiring rapid absorption Weekly agents (semaglutide, dulaglutide, exenatide extended-release) Generally have minimal impact on oral contraceptive effectiveness Warfarin/coumarin anticoagulants More frequent INR monitoring may be advised when starting GLP-1 therapy Oral semaglutide (Rybelsus) has specific administration requirements (taking on an empty stomach with a small amount of water) to ensure proper absorption