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Post-hoc power calculations (G*Power 3.1) using the reported effect sizes (Cohens d 0.250.40) indicate that 80% power to detect a minimal clinically important difference of 1 cm on the VAS pain scale would require 128200 completers per arm

Nutrients, 11(9), 2077.External link 3.Kim, J.K., et al

Cell Death Discov 6:132 Dreischer P, Duszenko M, Stein J, Wieder T (2022) Eryptosis: programmed death of nucleus-free, iron-filled blood cells

Protecting muscle requires adequate protein intake (1.2 to 1.6g per kilogram of body weight daily) and structured resistance training two to three times per week while on the medication

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For screened patients inside a supervised, short-term program like those at Rapid Weight Loss Centers, yes, phentermine is considered safe when taken as directed