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A 1mg intranasal dose could theoretically match or exceed the brain exposure of a 3mg oral dose, though nasal administration introduces variability based on mucosal absorption and nasal cavity drainage

Moreover, the amounts of lipoic acid available in dietary supplements (50-600 mg) are likely as much as 1,000 times greater than the amounts that could be obtained from the diet

This may suggest that a subset of carriers may already exhibit early disease-associated changes despite not fulfilling current diagnostic criteria

ZhuHBiDZhangYKongCDuJWuXet al

Kleinman HK, Sosne G

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