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Studies have used MT-II in direct comparison with MT-1 to characterise how cyclisation of the -MSH pharmacophore core changes receptor subtype selectivity , establishing that constraining the heptapeptide into a cyclic conformation shifts selectivity toward MC3R/MC4R relative to the linear tridecapeptide that preferentially activates MC1R

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International Journal of Molecular Sciences , 20(16), 3905

If you want to change muscle composition, think weeks and months, with dosing tied to meals