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In addition, there is substantial room for error in prescribing GLP-1s, and patients should be regularly monitored to ensure proper dosage, side effect management, and diet/exercise guidance

Some patients experience dose tolerancewhere their initial maintenance dose becomes less effective after 612 months of consistent use

Recently, the expression of the GLP-1 receptor has been reported in the knee joint of rat cartilage 35 and in chondrocytes from mouse tracheal cartilage 36 , but has never been described in OA patients or in mouse articular cartilage and synovial membrane

GLP-1 receptor agonist medications mimic this hormones effects, leading to slower stomach emptying, better insulin sensitivity, and reduced hunger

It investigated which low dose ranges are used in research studies