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Redox Biol 2019;22:101148

About Tirzepatide About Tirzepatide Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors, under active clinical evaluation

Dual agonists typically target GLP-1R, GIP (glucose-dependent insulinotropic polypeptide) or IGF (insulin-like growth factor) receptors, while triple agonists target GLP-1R, GIPR, and the glucagon receptor (GCGR)

"Retatrutide Clinical Development: Safety and Efficacy in Phase 2 Trials." Clinical Endocrinology and Metabolism Review, 2024