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doi: 10.1038/s41574-019-0176-8 9 MaCAvenellABollandMHudsonJStewartFRobertsonCet al

Developed by Theratechnologies Inc., it underwent phase II trials in the mid-2000s for GH deficiency (GHD) and HIV lipodystrophy but was discontinued, with reported reasons including hypersensitivity reactions, including an anaphylaxis-like reaction in one trial participant Wong et al (2008) [Note: Abstract only

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However, metformin remains the first-line drug for overall diabetes management

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Without it, women face a sharp rise in metabolic syndrome, type 2 diabetes, and cardiovascular diseasethe very conditions GLP-1 agonists target