A blinded extension among participants with baseline BMI 35 reached 30.3% mean weight loss at 104 weeks
[DOI] [PubMed] [Google Scholar] Ji JJ, Lin Y, Huang SS, Zhang HL, Diao YP, Li K
Metabolic rate undergoes a gradual adjustment period
This is partly because the body's weight set point defends against the lower weight, and partly because GLP-1 receptors in the brain that were being continuously stimulated are no longer activated
When Switching Makes Sense and When It Doesnt Switching to tirzepatide may be a good option if: Weight loss has stalled despite consistency Side effects are limiting progress Appetite control remains a challenge Staying on semaglutide may make sense if: Weight loss is steady Side effects are minimal The current dose is working well The right choice depends on how your body is responding, not on comparisons alone
A 2025 study found that L-theanine also extends lifespan in organism models by reducing advanced glycosylation end products, one of the biological processes most directly linked to cellular aging
