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[180] The tapering schedule may depend on the duration of therapy, with slower tapering required for patients who have received treatment for extended periods

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Although various global protein, transcriptional and epigenetic changes may contribute to PCOS-specific dysfunctions 158,180,181 , the precise roles of specific cell types within adipose tissue, their molecular functions and inter-tissue communication are yet to be defined

When clinical indicators suggest class 1, 2, or 3 obesity, or morbid obesity with excess calories, the unspecified code represents a significant RAF capture miss

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Thus, the residues forming the dimeric interface should also constitute a good criterion for distinguishing monomeric from dimeric proteins