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Alcohol is one of the primary substances that depletes glutathione in the liver

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For comparison, we treated cells with tunicamycin (TUN, a widely-used ER stress inducer) which did not alter phospho-GCN2 (T899), but reduced the mobility of PERK, indicative of its increased phosphorylation (Fig

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10.1038/s41582-021-00530-8 68 HazlettH

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