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The peptide demonstrates dual-phase mechanisms: acute phase preservation of ischemic tissue through anti-apoptotic signaling via Akt activation, and chronic phase activation of cardiac progenitor cells (c-kit+ populations) that contribute to myocardial repair through both structural replacement and paracrine support, with studies showing 200% increases in progenitor cell mobilization and cardiac homing

Neurology 85 , 4047 (2015)

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The metal-peptide bond can dissociate at elevated temperatures, releasing free copper and destroying the active complex