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Common Side Effects: Mild skin irritation (redness, itching or burning sensation) Dryness and peeling Increased sensitivity to sunlight Less Common Side Effects: Allergic reactions Uneven skin tone Acne or breakouts Rare Side Effects: Skin thinning (especially with steroid-based creams) Long-term changes in skin pigmentation Tip: Always use freckle removal creams as directed and apply a broad-spectrum sunscreen daily to help protect your skin and minimise potential side effects

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Data checks before registering study protocols for health care database analyses

doi: 10.1016/S0083-6729(05)72005-7 45 NiuS

Figure 2 NASPGHAN guidelines indicate alarm symptoms and signs that may help clinicians in identifying those patients in whom further diagnostic testing is appropriate (Table 2, Figure 2)

The kidneys are also an important organ in ammonia metabolism