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GIPRs have been localized to human pancreatic -cells, and intravenous GIP infusion activates GIPR and intracellular signaling in pancreatic -cells, augmenting glucagonotropic effects in hypoglycemic conditions in humans (130)

These are typically administered via subcutaneous injection at standard therapeutic doses as recommended in the manufacturer's Summary of Product Characteristics (SmPC) and regulatory bodies such as the MHRA

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