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Loss of CI resulted in reduced expression of transcription networks involved in insulin sensitivity, PPAR signalling and fatty acid metabolism

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A longer dose titration period and lower starting doses (100 mcg once daily at bedtime, leveraging the nocturnal GH surge) are appropriate in this group

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o Look for B12 on labels as cyanocobalamin, methylcobalamin, adenosylcobalamin, or hydroxocobalamin

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