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Trimethylamine N-oxide exacerbates cardiac fibrosis via activating the NLRP3 Inflammasome

This was addressed pharmacologically by identifying PAMs, including BPAM and the plant lectin Concanavalin A (ConA), which slowed down desensitization to the timescale of seconds (Figure 9A)

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When the amount of non-ionic surfactants and cholesterol increases, the amount of the hydrophobic domain and the number of niosomes produced raises and hence increases in entrapment efficiency and particle size 56,57