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Clinical safety and efficacy in humans have not been established

Cycle length is short: 4 to 6 weeks maximum

doi:10.1007/pl00014300 [27] McNulty H, Dowey le RC, Strain JJ, et al

Such heterogeneity is a likely determinant of outcome and is considered a major barrier to developing or optimizing therapeutics for the brain-injured patient (Saatman et al., 2008)