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99 Until more robust trials confirm their safety specifically in patients with reduced LVEF, GLP-1 RAs should be used cautiously in this population

It leads to stress-eating, skipped doctor visits, and avoidance of movement

The theory behind microdosing is that a smaller dose still activates those pathways enough to see benefits, without triggering the aggressive nausea, fatigue, and hair thinning that higher doses can cause

Nausea, vomiting, and diarrhea are common during dose escalation

The first to file in the US gets a 180-day period of exclusivity during which it can be the sole marketer of the generic version

Figure 3 and Additional file 1: Fig