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However, clearance can markedly affect the extent of availability because it determines the extraction ratio (equation [8a])

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Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, Obrien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander heiden MG (2016) Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer