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An increase in liver enzymes, and skin-related side effects, such as cutaneous hyperesthesia, have also been observed

ApoE is also pivotal in tau pathology, tau-mediated neurodegeneration, and the microglial response to AD-related pathologies

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These challenges include the limited stability and bioavailability of bioactive ingredients in vivo , complex mechanisms of action, inadequate dosage and safety evaluations, and regulatory barriers

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