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If you have heart disease, some tablets are safer than others

FDA approval was based on the SOUL cardiovascular outcomes trial (CVOT) that demonstrated a 14% relative reduction in risk of MACE in patients treated with Rybelsus 14 mg orally once daily for approximately 5 years compared to those who received placebo

Importantly, overexpression of the GLP-1 metabolites GLP-1(937) and GLP-1(2837), which do not activate the classical GLP-1R, showed similar vascular protective effects, suggesting receptor-independent effects of GLP-1 (3)

It is not safe to quit the medication on their own for people managing type 2 diabetes

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This is the most troubling category of negative reviews