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10.1111/j.1365-4632.2007.03393.x

Although a recent clinical trial investigating IMC-A12 and cetuximab in colorectal cancer patients did not show a benefit with IGF-1R inhibition [60], study patients were resistant to prior anti-EGFR therapy and staining for activated AKT, a marker of EGFR and IGF-1R signaling, did not correlate with outcome

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[3] Because MK-677 activates the ghrelin receptor, it is accurately described as a ghrelin receptor agonist or ghrelin mimetic. At the cellular level, GHSR1a is a Gq-coupled receptor: activation drives phospholipase C, inositol trisphosphate, and a rise in intracellular calcium in pituitary somatotrophs, which triggers GH release