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Potential candidates for off-label use: Clinicians may consider GLP-1 therapy for women with PCOS who meet the following criteria: Overweight or obesity (particularly BMI 30 kg/m) with PCOS Insulin resistance or impaired glucose tolerance Inadequate response to lifestyle modification and other treatments No contraindications to GLP-1 therapy Not planning pregnancy in the immediate future Contraindications and precautions: GLP-1 receptor agonists are contraindicated in pregnancy and breastfeeding

However, people who are actively losing weight especially those who are losing relatively large amounts of weight on GLP-1 drugs need to be mindful of the amount of protein they are consuming and the amount of exercise they are getting

In vitro, GLP-1 enhanced brain-derived neurotrophic factor (BDNF) secretion and ameliorated mitochondrial dysfunction and cell toxicity via cAMP/PKA activation in A-treated astrocytes [50]

doi:10.1152/ajprenal.00729.2010 262

Above all the other benefits Ive found of taking a GLP-1, this has absolutely been the biggest game-changer for me

But I do think there are some potential benefits