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Furthermore, inhibition of TGF--mediated activation of ALK4/5/7 in osteoarthritic human FLS prevented the induction of the pyridinoline cross-linking enzyme pro-collagen lysine-2-oxoglutarate 5-dioxygenase 2 ( PLOD2 ), which suppresses collagen degradation, as well as CTGF and COL1A1

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