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Notably, feMPI detected cardiac injury approximately 48 h earlier than conventional clinical detection methods, providing a powerful tool for MI/R-induced ferroptosis investigation and offering insights for molecular imaging and drug development targeting ferroptosis-related therapies (63)

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Vlaardingerbroek H, Vermeulen MJ, Rook D, van den Akker CH, Dorst K, Wattimena JL et al

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The study results suggested that polyphenol consumption escalated with age, with a more pronounced increase observed in male subjects

Key challenges include unresolved long-term biosafety profiles, the absence of standardized large-scale manufacturing protocols, and the insufficient investigation into their potential effects on autophagy and ferroptosis in normal tissues