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The antidote
However, its still unclear whether the reduced effect on appetite after 24 weeks is due to the body adapting to the weight loss or if the appetite-suppressing effect of TE itself diminishes over time
Indeed, research attention in the last decade has focused significantly on antioxidants targeting the mitochondria, and it appears that the focus is shifting from more traditional antioxidants (see Figure 2)
Combination approaches that pair GSH depletion with ferroptosis induction, immunotherapy, or chemotherapy may help overcome resistance, while standardized manufacturing and rigorous toxicity evaluation will be critical for regulatory approval
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