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(2024) 17(12):e70020
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Preclinical and clinical data suggest that FXR and PPAR dual modulators can improve insulin sensitivity, reduce hepatic steatosis, and attenuate fibrosis, which may complement the actions of GLP-1/GIP/GCG receptors agonists
It inhibits the production of melanin, the pigment responsible for skin color, leading to a lighter and more even skin tone
The pathophysiology of DDES is complex, involving lacrimal gland mitochondrial dysfunction, neuro-inflammation, ocular surface dysbiosis, and meibomian gland dropout [122,123,124]