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The safety profile of empagliflozin was comparable to that observed in adult patients: hypoglycemia was the most frequently reported adverse event, with higher rates for those on active drug treatment compared with placebo

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To better understand the inhibitory effects, LPS-induced NF-B activation and MAPK phosphorylation were analyzed

The STEP-HFpEF and STEP-HFpEF DM trials evaluated the efficacy of weekly semaglutide treatment versus placebo in patients with obesity-related HFpEF, both with and without diabetes, respectively

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