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Increased release of glutamate from presynaptic terminals activates N -methyl-D-aspartate (NMDA) receptors on postsynaptic terminals to lead to a widespread neuronal depolarization or spreading depression, further disrupting the sodium ion, potassium ion, and calcium ion equilibria (Bouley et al., 2019)

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FIfty years of thiazide diuretic therapy for hypertension

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Some of the most common symptoms include: Nausea Vomiting Diarrhea Similar to any kind of stomach illness, youre just not able to keep food down, so you can get dehydrated and feel ill for a long period of time, Johnson says

The concern is physiological and behavioral rather than a classic drug-drug interaction