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T2DM is the underlying cause of many complications, among which, cardiovascular diseases (CVDs) are mainly responsible for the high rates of morbidity and mortality

Cardiovascular (CV) events are strongly related to interleukin-6 (IL-6) and C-reactive protein (CRP), independently from the classical CV risk factors [1,2,3,4]

This suppression occurs just at or above fasting glucose levels, hence preserving counterregulatory responses to hypoglycaemia (Holst 2007)

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Rarely, they may lead to severe nausea or vomiting, which could result in more serious complications