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175 For the PPP enzymes, recent studies have discovered some inhibitors targeting on G6PD, such as NADP + analogs, the competitive inhibitor 6-aminonicotinamide (6-AN), noncompetitive inhibitors epiandrosterone and dehydroepiandrosterone (DHEA) which reduces the availability of NADPH and inhibits the cell growth

Hormones, insulin resistance, medications, and stress all play a role

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Dysregulation of GSH synthesis was associated with many diseases, such as diabetes mellitus, cholestatic liver disease, endotoxemia, alcoholic liver disease, cancer, and neurodegenerative diseases

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