Mbemba FT, Remacle J, Paulus J, Anita A, Timi-Timi A, Kwilu N
(Eli Lilly, which makes another GLP-1 drug, tirzepatide, was also included in the lawsuit.) The new research, based on health insurance claims from 2006 to 2020 from more than 5,000 patients in the U.S., looked at how many people developed one of four serious gastrointestinal problems biliary disease, gastroparesis, pancreatitis or bowel obstructions after they were prescribed one of the weight loss drugs
Clinical trials for tirzepatide did not find a major risk of dangerous heart rhythms or serious heart problems in most patients
Tirzepatide works on two hormone pathways instead of one (GLP-1 and GIP)
10.1021/acs.molpharmaceut.0c00326 55
Importantly, these determinants are interdependent and may amplify or attenuate one another within a complex host-microbe-drug network (128)