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J Mol Neurosci (2019) 67(4):50410

The ,-unsaturated enone moiety of resorcylic acid lactones is susceptible to Michael addition reaction with a conserved cysteine residue (Cys166 in human ERK2) (95)

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Deciding between 5-Amino-1MQ and AOD-9604 depends on your goals, training phase, and tolerance for research compounds