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10.1210/en.2013-1934
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Clinical trials assessing the effects of GH treatment in patients with obesity have shown consistent reductions in total adipose tissue mass, in particular abdominal and visceral adipose tissue depots
The minimal differences in genetic effect estimates (Beta difference range: 0.001-0.003) between female and sex-combined data for the exposure-mediator relationships indicate that sex is not a major effect modifier at this step, validating the use of sex-combined data for these mediators in our primary analysis
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