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Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

IL-6 has shown also to induce the secretion of intestinal GLP-1, indirectly via the release of adipocytes derived Leptin (227)

Hakkarainen and S

However, taking multiple medications at the same time can be confusing and concerning for patients

Semaglutide is meant to be titrated up gradually, with most individuals finding the 0.50mg-1.00mg dose to be the "sweet spot" for weight loss

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