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36 Through the cGAMPSTINGTBK/IKK axis, it induces NF-B-dependent expression of inflammatory cytokines such as IL-6 and CXCL10, promoting the SASP

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Tirzepatide activates both the GIP and GLP-1 receptors, a dual-incretin mechanism, while semaglutide targets the GLP-1 receptor alone

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In the pharmacological interaction with immune receptors (p-I) model, the drug noncovalently inserts in the immunological synapse, altering activation