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The most frequently reported adverse events were gastrointestinal-related, typically mild to moderate in severity
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Women with PCOS now officially renamed Polyendocrine Metabolic Ovarian Syndrome (PMOS) following a May 2026 international consensus published in The Lancet or insulin resistance more broadly often have a slower start on Retatrutide
1 Beyond diabetes and obesity Cardiovascular disease In March 2024, the US Food and Drug Administration (FDA) approved Wegovy (semaglutide) for adults with cardiovascular disease (CVD) and either obesity and overweight to reduce the risk of cardiovascular death, heart attack, and stroke
a priority review could shorten this
GLP-1 receptor agonists carry a boxed warning regarding thyroid C-cell tumors observed in animal studies, and while the relevance to humans remains uncertain, patients with personal or family history of medullary thyroid carcinoma should not use these medications
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