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The deeper reality is that GLP-1 medications reshape your microbiome, and the state of your microbiome determines how you experience those digestive changes

Gradual dose titration Work with your prescriber to titrate your GLP-1 medication slowly

The science behind Akkermansia and GLP-1 is not made up

Work with your healthcare provider to adjust meal-time insulin doses and timing when starting or adjusting a GLP-1 agonist

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Once you settle in at your maintenance dose, gastrointestinal side effects should improve and ultimately go away (although for some people, you may feel mild side effects the day after you give yourself the injection)