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Independent laboratory testing of semaglutide products sold as research chemicals found actual purity levels between 7% and 14%

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However, this still leaves two thirds of the heart benefits of semaglutide unexplained

Our findings confirm that longer diabetes duration is associated with a lower glycaemic response to GLP-1 RAs [3, 6, 16], probably due to declining beta cell function, as intact insulin secretion is necessary for a robust glycaemic response to this drug class [1, 3]